With powerful lasers breaking the Petawatt barrier, applications for laser-accelerated particle beams are gaining more interest than ever. Ion beams accelerated by intense laser pulses foster new ways of treating cancer and make them available to more people than ever before. Laser-generated electron beams can drive new compact x-ray sources to create snapshots of ultrafast processes in materials. With PIConGPU laser-driven particle acceleration can be computed in hours compared to weeks on standard CPU clusters. We present the techniques behind PIConGPU, detailed performance analysis and the benefits of PIConGPU for real-world physics cases.