With GPU-accelerated simulations, frames-per-second, in-situ visualization and visual analytics becoming a reality, it increases scalability of codes which allows to reduce the time to obtain a solution significantly. This also makes it possible to run large-scale parameter surveys for optimization. We will present recent activities on integrating complex particle accelerator simulations into a reconstruction loop for matching experimental measurements to simulation. This requires to put simulations in a loop with large-scale data analysis, sythetic diagnostics, image reconstruction techniques and interactive in-situ visualization. We will show how the different building blocks of such a tool chain can be accelerated using GPUs and discuss the combination of these tools.