At CSIRO Data61, we're building the next generation of science platforms that exploit GPU computing to dramatically accelerate the time to discovery and the pace of innovation in science and industry. Scientific applications routinely generate huge amounts of data. In response to these trends, we've developed and deployed a new breed of GPU-accelerated big data technologies, earth system modeling tools, and machine learning capabilities. We'll present examples of our work in big data analytics, earth system modeling, and deep learning that clearly demonstrate the value that GPU computing can deliver to research organisations and industry. CSIRO has been at the forefront of GPU computing since 2009 and was one of the first NVIDIA CUDA Research Centers.