Get an overview of how GPUs are used by computational astrophysicists to perform numerical simulations and process massive survey data. Astrophysics represents one of the most computationally heavy sciences, where supercomputers are used to analyze enormous amounts of data or to simulate physical processes that cannot be reproduced in the lab. Astrophysicists strive to stay on the cutting edge of computational methods to simulate the universe or process data faster and with more fidelity. We'll discuss two important applications of GPU supercomputing in astrophysics. We'll describe the astrophysical fluid dynamics code CHOLLA that runs on the GPU-enabled supercomputer Titan at Oak Ridge National Lab and can perform some of the largest astrophysical simulations ever attempted. Then we'll describe the MORPHEUS deep learning framework that classifies galaxy morphologies using the NVIDIA DGX-1 deep learning system.