We'll explore NVIDIA GVDB Voxels, a new open source SDK framework for generic representation, computation, and rendering of voxel-based data. We'll introduce the features of the new SDK and cover applications and examples in motion pictures, scientific visualization, and 3D printing. NVIDIA GVDB Voxels, based on GVDB Sparse Volume technology and inspired by OpenVDB, manipulates large volumetric datasets entirely on the GPU using a hierarchy of grids. The second part of the talk will cover in-depth use of the SDK, with code samples, and coverage of the design aspects of NVIDIA GVDB Voxels. A sample code walk-through will demonstrate how to build sparse volumes, render high-quality images with NVIDIA OptiX integration, produce dynamic data, and perform compute-based operations.