This talk will overview the fields of Personalised Computational Medicine and In Silico Clinical Trials, which are revolutionizing Medicine and Medical Product Development. This talk will introduce these concepts, provide examples of how they can transform healthcare, and emphasize why artificial intelligence and machine learning are relevant to them. We will also explain the limitations of these approaches and why it is paramout to engage in both phenomenological (data-driven) and mechanistic (principle-driven) modelling. Both areas are in desperate need for better infrastructures -sofrware and hardaware- giving access to computational and storage resources. The talk will be thought-provoking and eye-opening as to opportunities in this space for researchers and industries alike.