With advances in image acquisition and numerical simulation techniques, fields ranging from medical imaging to astrophysics are producing data with very large spatial and temporal resolutions. Interactive visualization techniques are crucial to understand and isolate features from the resulting large time dependent 4D volumetric data. This presentation explores the various rendering methods such as texture slicing, raycasting in graphics and cuda as well as hybrid approaches showing their promises and pitfalls. It is common for 4D data to exceed the graphics memory capabilities and approaches for efficiently streaming data such as PBO's and CPU/GPU asynchronous modes are explained. We conclude with a discussion on how other related solutions from NVIDIA can be integrated, specifically focusing on 3D Vision stereo and NVScale middleware to harness multiple GPU's for distributed rendering.