GTC ON-DEMAND

 
SEARCH SESSIONS
SEARCH SESSIONS

Search All
 
Refine Results:
 
Year(s)

SOCIAL MEDIA

EMAIL SUBSCRIPTION

 
 

GTC ON-DEMAND

Computational Biology & Chemistry
Presentation
Media
Visualizing ATP-Dependent Substrate-Processing Dynamics of the Human 26S Proteasome at Near-Atomic Resolution
Abstract:
We'll discuss how we visualized ATP-dependent substrate-processing dynamics of the human 26S proteasome at near-atomic resolution with cryo-electron microscopy. We'll present cryo-EM structures of the 26S proteasome in seven conformational states at a resolution of 2.8-3.6mm, captured during polyubiquitinated protein degradation. We will discuss how these structures visualize a continuum of dynamic substrate-proteasome interactions from ubiquitin recognition to processive substrate translocation.
 
Topics:
Computational Biology & Chemistry, Computational Physics
Type:
Talk
Event:
GTC Silicon Valley
Year:
2019
Session ID:
S9716
Streaming:
Download:
Share: