Protecting crew health is a critical concern for NASA in preparation of long duration, deep-space missions like Mars. Spaceflight is known to affect immune cells. Splenic B-cells decrease during spaceflight and in ground-based physiological models. The key technical innovation presented by our work is end-to-end computation on the GPU with the GPU Data Frame (GDF), running on the DGXStation, to accelerate the integration of immunoglobulin gene-segments, junctional regions, and modifications that contribute to cellular specificity and diversity. Study results are applicable to understanding processes that induce immunosuppressionlike cancer therapy, AIDS, and stressful environments here on earth.