The increasing availability of large medical imaging data resources with associated clinical data, combined with the advances in the field of machine learning, hold large promises for disease diagnosis, prognosis, therapy planning and therapy monitoring. As a result, the number of researchers and companies active in this field has grown exponentially, resulting in a similar increase in the number of papers and algorithms. A number of issues need to be addressed to increase the clinical impact of the machine learning revolution in radiology. First, it is essential that machine learning algorithms can be seamlessly integrated in the clinical workflow. Second, the algorithm should be sufficiently robust and accurate, especially in view of data heterogeneity in clinical practice. Third, the additional clinical value of the algorithm needs to be evaluated. Fourth, it requires considerable resources to obtain regulatory approval for machine learning based algorithms. In this workshop, the ACR and MICCAI Society will bring together expertise from radiology, medical image computing and machine learning, to start a joint effort to address the issues above.
There is large promise in machine learning methods for the automated analysis of medical imaging data for supporting disease detection, diagnosis and prognosis. These examples include the extraction of quantitative imaging biomarkers that are related to presence and stage of disease, radiomics approaches for tumor classification and therapy selection, and deep learning methods for directly linking imaging data to clinically relevant outcomes. However, the translation of such approaches requires methods for objective validation in clinically realistic settings or clinical practice. In this talk, I will discuss the role of next generation challenges for this domain.
Big data analytics methods for the large scale analysis of imaging, genetic, laboratory, and clinical data have great potential to improve our understanding of disease, and to improve disease diagnosis and prognosis. Both classical machine learning (e.g. radiomics, multi feature classification) and deep learning methods are currently used in these domains. In this talk, I will present the results and challenges for both approaches to make impact in the context of a number of applications. Specifically, we will discuss early and differential diagnosis and improved prognosis of dementia, and improved neuro tumor characterization and treatment response prediction.