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GTC ON-DEMAND

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Abstract:
We'll discuss how we visualized ATP-dependent substrate-processing dynamics of the human 26S proteasome at near-atomic resolution with cryo-electron microscopy. We'll present cryo-EM structures of the 26S proteasome in seven conformational states at a resolution of 2.8-3.6mm, captured during polyubiquitinated protein degradation. We will discuss how these structures visualize a continuum of dynamic substrate-proteasome interactions from ubiquitin recognition to processive substrate translocation.
We'll discuss how we visualized ATP-dependent substrate-processing dynamics of the human 26S proteasome at near-atomic resolution with cryo-electron microscopy. We'll present cryo-EM structures of the 26S proteasome in seven conformational states at a resolution of 2.8-3.6mm, captured during polyubiquitinated protein degradation. We will discuss how these structures visualize a continuum of dynamic substrate-proteasome interactions from ubiquitin recognition to processive substrate translocation.  Back
 
Topics:
Computational Biology & Chemistry, Computational Physics
Type:
Talk
Event:
GTC Silicon Valley
Year:
2019
Session ID:
S9716
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